Better-preserved hair follicles mean a fuller, healthier head of hair. At Dr Bonaros, we use Hypothermosol in hair transplants as a holding solution.
This advanced preservation medium supports cells by reducing oxidative stress and metabolic activity. This helps sustain hair graft survival from extraction to implantation.
Find out why Hypothermosol is an ideal holding solution, preferred globally by experienced hair transplant surgeons.
Biolife Solutions specifically formulated HypoThermosol FRS to protect living cells and tissues. Adenosine triphosphate (ATP), often in an ATP liposomal formulation, is added to HypoThermosol to support intracellular energy metabolism (how cells make and use energy) during cold storage.
Read on to learn about HypoThermosol and its use in Follicular Unit Extraction (FUE) hair transplant surgery.
HypoThermosol FRS is a specialised graft storage solution used to preserve hair follicles at optimal hypothermic temperatures (+2°C to +8°C).
This advanced storage medium extends the viability window for harvested follicular unit grafts. This gives surgeons more time to perform meticulous, high-quality transplant procedures.
Its carefully balanced formulation makes HypoThermosol FRS particularly effective for hair restoration. It directly addresses the cellular stress that hair grafts experience during storage by offering.
Quality and safety are foremost in any medical procedure, so HypoThermosol FRS is manufactured to meet United States Pharmacopoeia (USP) sterility criteria.
It also complies with USP endotoxin testing standards under strict Current Good Manufacturing Practice (cGMP) protocols.
Read MoreHair transplant success relies on maintaining graft viability during storage. Most storage solutions are isotonic solutions like normal saline and modified cell culture media designed for body temperature. However, hair transplantation requires a different approach.
Transplanted hair follicles are routinely stored in a cooled (hypothermic) state, which reduces metabolic stress and protects delicate cellular structures.
This is where HypoThermosol® FRS makes a crucial difference in hypothermic storage.
By providing specialised protection during the critical storage phase, HypoThermosol FRS ensures that transplanted hair follicles maintain their growth potential and significantly extend viability. This leads to more successful hair transplantation procedures.
Clinical studies demonstrate improved outcomes when using HypoThermosol® with ATP as a graft storage solution during hair transplantation.
In a controlled study, hair grafts were stored at 4°C for five days in saline, HypoThermosol alone, and HypoThermosol with ATP.
Clinical studies demonstrate improved outcomes when using HypoThermosol® with ATP as a graft storage solution during hair transplantation. In a controlled study, hair grafts were stored at 4°C for five days in saline, HypoThermosol alone, and HypoThermosol with ATP.
After 18 months, graft survival rates were:
A separate 96-hour storage trial confirmed these findings, with HypoThermosol + ATP consistently outperforming saline-based storage.
The enhanced preservation appears to reduce follicle damage and support early post-transplant growth. ATP’s anti-apoptotic properties may improve cellular survival during the critical storage period, leading to more predictable hair growth outcomes.
These results suggest that HypoThermosol + liposomal ATP offers a clinically meaningful advantage for hair restoration procedures, particularly when extended graft storage is required.
Learn more about using HypoThermosol as a preservation medium during hair transplant through answers to common FAQs.
HypoThermosol is an odour-free solution with hypoallergenic properties. It contains no serum or proteins, reducing the risk of allergic reactions. It is generally very well-tolerated in hair transplant procedures.
While the solution itself is not commonly associated with side effects, patients may experience mild irritation or redness at the donor area or recipient sites. These reactions are typically related to the procedure itself and tend to resolve quickly.
Always follow your post-hair restoration procedure instructions carefully and see a medical professional immediately if you experience adverse effects.
Hair graft survival outside the body depends on storage conditions and time. Research by the International Society of Hair Restoration Surgery (ISHRS) shows that low temperature storage at 4°C is optimal when out-of-body time exceeds six hours.
While scalp tissue samples can survive briefly at room temperature, viability decreases with extended exposure. Beyond six hours, survival rates decline significantly regardless of temperature.
Specialised solutions like HypoThermosol act as nutrient-rich fertiliser for grafts. Some formulations contain liposomal ATP to support tissue samples’ cellular preservation during extended storage beyond the critical six-hour threshold.
Count on Dr Bonaros to personally handle your entire FUE hair transplant procedure with care.
No technicians or handoffs, just expert care throughout. Book your Zoom consultation today.
At Dr Bonaros, we combine compassionate, individualised care with cutting-edge hair restoration technology. We offer advanced surgical transplantation and innovative non-surgical treatments tailored for both men and women experiencing hair loss.
Dr Bonaros is the only Scottish practitioner who holds membership in the ISHRS. His credentials are further distinguished by full membership in the British Association of Hair Restoration Surgery (BAHRS).
These affiliations reflect Dr Bonaros’ unwavering commitment to excellence and patient satisfaction. Additionally, as a Diplomate of the American Board of Hair Restoration Surgery (ABHRS), Dr Bonaros brings unparalleled expertise to every procedure.
Ready to see what’s possible? Explore the life-changing results and natural appearance our clients have achieved with doctor-performed hair transplant solutions.
Dr Bonaros uses premium materials, such as HypoThermosol, in hair transplant procedures for safe results. Complete the form for a free hair transplantation assessment in your inbox.