Diffuse Unpatterned Alopecia (DUPA) is a relatively uncommon condition, affecting only 2–6% of men with hair loss. Unlike with androgenetic alopecia, DUPA lacks a stable donor zone considered safe for surgical transplantation.
With DUPA, hair thinning takes place along the front, top, back and sides of the scalp, and the majority of hairs are or will eventually become miniaturised. Hair transplantation, therefore, is not a viable treatment option.
A hair transplant performed on a patient with DUPA may look good for a few years, but the transplanted hairs are likely to thin out over time. In addition, existing hair in the donor area may appear severely depleted. Keeping this in mind, it is best to manage DUPA with non-surgical medical treatment options like minoxidil, finasteride, and low-level laser therapy.

Hair transplantation is generally not recommended for patients with DUPA or Alopecia areata