About HypoThermosol in Hair Transplants
Biolife Solutions specifically formulated HypoThermosol FRS to protect living cells and tissues. Adenosine triphosphate (ATP), often in an ATP liposomal formulation, is added to HypoThermosol to support intracellular energy metabolism (how cells make and use energy) during cold storage.
Read on to learn about HypoThermosol and its use in Follicular Unit Extraction (FUE) hair transplant surgery.
What is HypoThermosol FRS?
HypoThermosol FRS is a specialised graft storage solution used to preserve hair follicles at optimal hypothermic temperatures (+2°C to +8°C).
This advanced storage medium extends the viability window for harvested follicular unit grafts. This gives surgeons more time to perform meticulous, high-quality transplant procedures.
Its carefully balanced formulation makes HypoThermosol FRS particularly effective for hair restoration. It directly addresses the cellular stress that hair grafts experience during storage by offering.
- Essential osmotic support through precisely calibrated ions and molecules
- Optimal pH maintenance with targeted pH buffering systems
- Powerful antioxidant protection that significantly reduces hair follicle cell death caused by apoptosis and necrosis
cGMP-Compliant Production for Consistent Quality
Quality and safety are foremost in any medical procedure, so HypoThermosol FRS is manufactured to meet United States Pharmacopoeia (USP) sterility criteria.
It also complies with USP endotoxin testing standards under strict Current Good Manufacturing Practice (cGMP) protocols.
This graft storage solution delivers a:
- Serum-free formulation
- Protein-free composition
- USP-grade components for the highest quality standards
HypoThermosol FRS produces the scientific precision and quality assurance needed to optimise patient outcomes and hair transplant surgery success.
How HypoThermosol Works in Hair Transplantation Procedures
Hair transplant success relies on maintaining graft viability during storage. Most storage solutions are isotonic solutions like normal saline and modified cell culture media designed for body temperature. However, hair transplantation requires a different approach.
Transplanted hair follicles are routinely stored in a cooled (hypothermic) state, which reduces metabolic stress and protects delicate cellular structures.
This is where HypoThermosol® FRS makes a crucial difference in hypothermic storage.
How It Works
- Creates an optimal hypothermic graft storage environment from the precise extraction to direct implantation
- Reduces metabolic demands on transplanted follicular unit grafts
- Minimises cellular stress during extended storage periods
- Maintains follicle integrity even during overnight preservation
Clinical Benefits
- Enhanced graft survival rates
- Improved transplantation outcomes
- Stronger, healthier hair grafts at implantation
- Better long-term hair restoration results
- Promotes follicle growth
By providing specialised protection during the critical storage phase, HypoThermosol FRS ensures that transplanted hair follicles maintain their growth potential and significantly extend viability. This leads to more successful hair transplantation procedures.
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Book a consultation with Dr Bonaros for a comprehensive assessment and tailored treatment plan.
Clinical Results of HypoThermosol & ATP Solution in Hair Transplant
Clinical studies demonstrate improved outcomes when using HypoThermosol® with ATP as a graft storage solution during hair transplantation.
In a controlled study, hair grafts were stored at 4°C for five days in saline, HypoThermosol alone, and HypoThermosol with ATP.
Clinical studies demonstrate improved outcomes when using HypoThermosol® with ATP as a graft storage solution during hair transplantation. In a controlled study, hair grafts were stored at 4°C for five days in saline, HypoThermosol alone, and HypoThermosol with ATP.
After 18 months, graft survival rates were:
- Saline solution: 0% regrowth
- HypoThermosol alone: 44% survival
- HypoThermosol + ATP: 72% successful growth
A separate 96-hour storage trial confirmed these findings, with HypoThermosol + ATP consistently outperforming saline-based storage.
The enhanced preservation appears to reduce follicle damage and support early post-transplant growth. ATP’s anti-apoptotic properties may improve cellular survival during the critical storage period, leading to more predictable hair growth outcomes.
These results suggest that HypoThermosol + liposomal ATP offers a clinically meaningful advantage for hair restoration procedures, particularly when extended graft storage is required.
FAQ
FAQs About Using HypoThermosol for Hair Graft Storage
Learn more about using HypoThermosol as a preservation medium during hair transplant through answers to common FAQs.
What are the potential side effects of HypoThermosol as a holding solution?
HypoThermosol is an odour-free solution with hypoallergenic properties. It contains no serum or proteins, reducing the risk of allergic reactions. It is generally very well-tolerated in hair transplant procedures.
While the solution itself is not commonly associated with side effects, patients may experience mild irritation or redness at the donor area or recipient sites. These reactions are typically related to the procedure itself and tend to resolve quickly.
Always follow your post-hair restoration procedure instructions carefully and see a medical professional immediately if you experience adverse effects.
How long can hair grafts survive outside the body?
Hair graft survival outside the body depends on storage conditions and time. Research by the International Society of Hair Restoration Surgery (ISHRS) shows that low temperature storage at 4°C is optimal when out-of-body time exceeds six hours.
While scalp tissue samples can survive briefly at room temperature, viability decreases with extended exposure. Beyond six hours, survival rates decline significantly regardless of temperature.
Specialised solutions like HypoThermosol act as nutrient-rich fertiliser for grafts. Some formulations contain liposomal ATP to support tissue samples’ cellular preservation during extended storage beyond the critical six-hour threshold.
Count on Dr Bonaros to personally handle your entire FUE hair transplant procedure with care.
No technicians or handoffs, just expert care throughout. Book your consultation today.
